Researchers conducting an analysis of ten different species found that humans — followed by ferrets and, to a lesser extent cats, civets and dogs — are the most susceptible animals to SARS-CoV-2 infection. (The study also found that ducks, rats, mice, pigs and chickens had lower or no susceptibility to infection compared to humans.)
The scientists argue that understanding SARS-CoV-2 infectivity across different species can better inform public health measures, helping reduce human contact with other susceptible animals and avoiding the potential prolongment of the COVID-19 pandemic.
Journal Reference: Javier Delgado Blanco, Xavier Hernandez-Alias, Damiano Cianferoni, Luis Serrano. In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species. PLOS Computational Biology, 2020; 16 (12): e1008450